Salima Begum, Bairam Khan, and Akbar
Humayun's advisor and Akbar's guardian (and regent), Bairam Khan's second wife was Babar's granddaughter, Salima Begum. After Bairam Khan was murdered in 1561, she became her cousin, Akbar's, second wife and Mughal Empress. Akbar's first wife, Ruqaiya, was his cousin as well.